Department of Radiology, University of California, San Diego, California, USA.
Int J Eat Disord. 2012 Apr;45(3):345-52. doi: 10.1002/eat.20944. Epub 2011 Jun 13.
Physiological and pharmacological studies indicate that altered brain serotonin (5-HT) activity could contribute to a susceptibility to develop appetitive and behavioral alterations that are characteristic of bulimia nervosa (BN).
Eight individuals recovered from BN (REC BN) and eight healthy control women were scanned with [11C]DASB and positron emission tomography imaging of the 5-HT transporter (5-HTT). Logan graphical analysis was applied, and parametric binding potential (BP(nondisplaceable (ND)) ) images were generated. Voxel-by-voxel t-tests and a region of interest (ROI) analysis were conducted.
REC BN had significantly lower [11C]DASB BP(ND) in midbrain, superior and inferior cingulate and significantly higher [11C]DASB BP(ND) in anterior cingulate and superior temporal gyrus in the voxel-based analysis. ROI analysis indicated lower [11C]DASB BP(ND) in midbrain (p = .07), containing the dorsal raphe, in REC BN, consistent with our earlier studies.
These preliminary findings of a small-scale study confirm and extend previous data suggesting that ill and recovered BN have altered 5-HTT measures, which potentially contribute to BN symptomatology and/or differential responses to medication.
生理和药理学研究表明，大脑 5-羟色胺（5-HT）活性的改变可能导致易感性的发展，表现为神经性贪食症（BN）的食欲和行为改变。
对 8 名从 BN 中康复的个体（REC BN）和 8 名健康对照女性进行 [11C]DASB 和 5-HT 转运体（5-HTT）的正电子发射断层扫描成像。应用 Logan 图形分析，并生成参数结合潜能（BP（不可置换（ND）））图像。进行体素间 t 检验和感兴趣区（ROI）分析。
基于体素的分析显示，REC BN 的中脑、上和下扣带回以及前扣带回和上颞叶的 [11C]DASB BP（ND）显著降低。ROI 分析表明，REC BN 的中脑（包含背侧缝际核）[11C]DASB BP（ND）降低（p=0.07），与我们早期的研究一致。
这项小规模研究的初步发现证实并扩展了先前的数据，表明患病和康复的 BN 存在 5-HTT 测量的改变，这可能导致 BN 症状和/或对药物治疗的不同反应。
