The University of the West Indies, Faculty of Medical Sciences, Department of Preclinical and Paraclinical Sciences, Trinidad and Tobago.
Arch Physiol Biochem. 2011 Oct;117(4):236-40. doi: 10.3109/13813455.2011.582875. Epub 2011 Jun 15.
The objective of the study was to determine the role of M-band component on serum protein electrophoresis and bone marrow biopsy in the diagnosis.
Data was collected on 34 patients with MM diagnosed and/or treated.
There were equal numbers of men 17 (50%) and women 17 (50%). All patients were first screened for the presence of M-Band using serum protein electrophoresis (SPE) followed by bone marrow biopsy as the confirmatory test. Only two patients screened negative by SPE. On the other hand six patients who tested positive by SPE were negative on biopsy. Thus the sensitivity of the SPE was 96% and specificity 71%. This means that 29 patients had an established diagnosis of MM. There was a slight male predominance when compared to females.
The data showed that the SPE and bone biopsy are the important tools in the diagnosis of multiple myeloma in a small developing country.
本研究旨在确定 M 带成分在血清蛋白电泳和骨髓活检中的诊断作用。
收集了 34 例 MM 诊断和/或治疗患者的数据。
男女患者数量相等，分别为 17 例（50%）和 17 例（50%）。所有患者均首先使用血清蛋白电泳（SPE）筛查 M 带的存在，然后进行骨髓活检作为确认试验。只有两名患者 SPE 筛查阴性。另一方面，SPE 阳性的六名患者活检为阴性。因此，SPE 的敏感性为 96%，特异性为 71%。这意味着 29 名患者被确诊为多发性骨髓瘤。与女性相比，男性略占优势。
数据表明，SPE 和骨髓活检是在一个小的发展中国家诊断多发性骨髓瘤的重要工具。
