Butterfield D A, Palmieri D A
Department of Chemistry, University of Kentucky, Lexington 40506-0055.
Free Radic Res Commun. 1990;9(3-6):361-6. doi: 10.3109/10715769009145695.
ESR spin labels specific for skeletal proteins or cell-surface sialic acid have been used to monitor the interaction of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its structural analogs with human erythrocyte membranes. The results suggest that THA significantly increases skeletal protein-protein interactions and may secondarily alter the physical state of the opposite side of the membrane. The fully aromatic analog of THA, 9-aminoacridine, showed even more pronounced effects on skeletal proteins than did THA. These results are discussed in relation to possible interaction sites of THA in erythrocyte ghosts and to potential mechanisms by which THA reportedly increases mental function of victims of Alzheimer's disease.
针对骨骼蛋白或细胞表面唾液酸的电子自旋共振（ESR）自旋标记已被用于监测9-氨基-1,2,3,4-四氢吖啶（THA）及其结构类似物与人红细胞膜的相互作用。结果表明，THA显著增加了骨骼蛋白-蛋白相互作用，并可能继而改变膜另一侧的物理状态。THA的全芳香族类似物9-氨基吖啶对骨骼蛋白的影响比THA更为显著。本文结合THA在红细胞血影中的可能相互作用位点以及据报道THA增强阿尔茨海默病患者心理功能的潜在机制对这些结果进行了讨论。
