Monoe Kyoko, Takahashi Atsushi, Katsushima Fumiko, Kanno Yukiko, Saito Hironobu, Abe Kazumichi, Yokokawa Junko, Ohira Hiromasa
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan.
Intern Med. 2011;50(12):1299-301. doi: 10.2169/internalmedicine.50.5022. Epub 2011 Jun 15.
A 34-year-old woman showed liver dysfunction for the first time at 3 months after delivery. Two years later, she was referred to our department with continued liver dysfunction. She fulfilled the criteria for primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap. Liver dysfunction improved after administration of ursodeoxycholic acid and bezafibrate. To the best of our knowledge this represents the second report of PBC-AIH overlap after delivery and we discuss immunological changes during the perinatal period.
一名34岁女性在产后3个月首次出现肝功能障碍。两年后，她因持续性肝功能障碍转诊至我科。她符合原发性胆汁性肝硬化（PBC）-自身免疫性肝炎（AIH）重叠综合征的标准。给予熊去氧胆酸和苯扎贝特后肝功能障碍有所改善。据我们所知，这是产后PBC-AIH重叠综合征的第二例报道，我们讨论了围产期的免疫变化。
