Skwarczynski Mariusz, Toth Istvan
Methods Mol Biol. 2011;751:297-308. doi: 10.1007/978-1-61779-151-2_18.
Disadvantages of classical vaccines, such as the risk of an autoimmune reaction, might be overcome by using a subunit vaccine containing the minimal microbial components necessary to stimulate appropriate immune responses. However, vaccines based on minimal epitopes suffer from poor immunogenicity and require the use of an additional immunostimulant (adjuvant). Only a few adjuvants have been permitted for use with vaccines intended for human administration. We have developed several vaccine candidates based on a lipid-core-peptide (LCP) system. This system has self-adjuvanting properties, and it can be used for the delivery of a variety of epitopes to produce vaccine candidates against a targeted disease. The LCP system is easily assembled by simple stepwise Boc solid-phase peptide synthesis.
传统疫苗存在一些缺点，比如有引发自身免疫反应的风险，而使用包含刺激适当免疫反应所需的最小微生物成分的亚单位疫苗或许可以克服这些缺点。然而，基于最小表位的疫苗免疫原性较差，需要使用额外的免疫刺激剂（佐剂）。只有少数佐剂被允许用于人类疫苗。我们基于脂质核心肽（LCP）系统开发了几种候选疫苗。该系统具有自我佐剂特性，可用于递送多种表位以生产针对目标疾病的候选疫苗。LCP系统通过简单的逐步Boc固相肽合成即可轻松组装。
