Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
Head Neck. 2011 Jul;33(7):954-8. doi: 10.1002/hed.21560. Epub 2010 Nov 12.
We investigated whether preoperative neoadjuvant chemotherapy is associated with increased surgical site infection (SSI) rate in patients with locally advanced oral cancer.
In this hospital-based study, we retrospectively reviewed over 2000 chart records of patients with oral cavity cancer from March 1994 to December 2007. Those who received neoadjuvant chemotherapy were identified and matched for age, sex, tumor classification, primary site, and reconstruction methods to hospitalized patients who did not receive chemotherapy. Data were analyzed for the relationship between chemotherapy and SSI.
A total of 306 patients were enrolled for final analyses. The overall postoperative SSI rate was 31.0%. The SSI rate in patients after neoadjuvant chemotherapy was similar to that in patients who did not receive the chemotherapy (33.3% vs 29.9%, p = .631).
Preoperative neoadjuvant chemotherapy was not associated with increased SSI rate in patients with locally advanced oral cancer.
我们研究了局部晚期口腔癌患者术前新辅助化疗是否与手术部位感染（SSI）发生率增加有关。
在这项基于医院的研究中，我们回顾性分析了 1994 年 3 月至 2007 年 12 月间超过 2000 例口腔癌患者的病历记录。确定并匹配接受新辅助化疗的患者与未接受化疗的住院患者的年龄、性别、肿瘤分类、原发部位和重建方法。分析化疗与 SSI 之间的关系。
共有 306 例患者纳入最终分析。总的术后 SSI 发生率为 31.0%。新辅助化疗后患者的 SSI 发生率与未接受化疗的患者相似（33.3%比 29.9%，p=0.631）。
术前新辅助化疗与局部晚期口腔癌患者 SSI 发生率增加无关。
