Huhman K L, Bunnell B N, Mougey E H, Meyerhoff J L
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Physiol Behav. 1990 May;47(5):949-56. doi: 10.1016/0031-9384(90)90023-w.
The effects of fighting and footshock on circulating adrenocorticotropin-like immunoreactivity (ACTH-LI), cortisol, corticosterone, beta-endorphin-like immunoreactivity (beta-EP-LI), and beta-lipotropin-like immunoreactivity (beta-LPH-LI) were examined. In the first experiment, catheterized males were paired with large, ovariectomized females for 15 min. Submissive males exhibited significant increases in plasma ACTH-LI, cortisol, corticosterone, and beta-EP-LI. In the second experiment, two males were paired to determine whether the hormonal response in submissive animals was different from that in dominant hamsters. The pattern and magnitude of the hormonal response was also compared to that following a commonly used stressor-footshock. Footshock was associated with large increases in each of the plasma hormones measured. Submission, but not dominance, was associated with smaller, but still significant, increases in ACTH-LI, cortisol, beta-EP-LI and beta-LPH-LI. The data indicate that fighting is not a generalized stressor. "Losing," in particular, appears to be an example of a biologically relevant stressor.
研究了打斗和足部电击对循环中的促肾上腺皮质激素样免疫反应性（ACTH-LI）、皮质醇、皮质酮、β-内啡肽样免疫反应性（β-EP-LI）和β-促脂素样免疫反应性（β-LPH-LI）的影响。在第一个实验中，将插管的雄性与大型去卵巢雌性配对15分钟。顺从的雄性血浆ACTH-LI、皮质醇、皮质酮和β-EP-LI显著增加。在第二个实验中，将两只雄性配对，以确定顺从动物的激素反应是否与占主导地位的仓鼠不同。还将激素反应的模式和幅度与常用应激源——足部电击后的情况进行了比较。足部电击与所测每种血浆激素的大幅增加有关。顺从而非主导，与ACTH-LI、皮质醇、β-EP-LI和β-LPH-LI较小但仍显著的增加有关。数据表明，打斗不是一种普遍的应激源。特别是“失败”，似乎是一种具有生物学相关性的应激源的例子。
