Collingridge G L, Singer W
Department of Pharmacology, School of Medical Sciences, University of Bristol, UK.
Trends Pharmacol Sci. 1990 Jul;11(7):290-6. doi: 10.1016/0165-6147(90)90011-v.
Excitatory amino acid receptors are the mediators of synaptic transmission at many synapses that can undergo use-dependent modifications of synaptic efficiency. They also play an essential role in the induction of these plastic changes. Graham Collingridge and Wolf Singer describe how NMDA receptors can endow synapses with hebbian-like properties and discuss how these may be used by vertebrates for associative learning and experience-dependent modifications of synaptic connections during development. The role of AMPA receptors in the maintenance of long-term potentiation is also discussed.
兴奋性氨基酸受体是许多突触处突触传递的介质，这些突触能够经历依赖于使用的突触效率修饰。它们在这些可塑性变化的诱导中也起着至关重要的作用。格雷厄姆·科林格里奇和沃尔夫·辛格描述了NMDA受体如何赋予突触类赫布特性，并讨论了脊椎动物如何利用这些特性进行联想学习以及在发育过程中对突触连接进行依赖于经验的修饰。还讨论了AMPA受体在维持长时程增强中的作用。
