Mosolov S N, Moshchevitin S Iu
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(4):121-5.
To break continuous psychoses, the ECT (5 to 10 sessions daily or every other day) was given to 20 patients with affective and schizoaffective psychoses, who suffered not less than 3 affective cycles a year and were resistant to the preventive therapy with lithium carbonate or carbamazepine++ on condition they were used continuously for a year. After the ECT was completed the preventive therapy carried out before was resumed. It has been discovered that the mean value of the total duration of the affective symptomatology for a year and the mean number of affective episodes seen during a year dropped considerably. Complete "breaking" of continuous psychosis with formation of a steady remission lasting not less than 5 to 6 months could be attained in 8 patients including 3 out of 8 patients with "rapid cycling" phenomena. The breaking effect of the ECT was more probable in patients with no signs of organic CNS failure, less disease standing and less period of the continuous disease proper as well as in the presence of well-defined remissions between the episodes, predominance and greater intensity of the depressive cycles as compared to the manic ones. The use of the ECT which brought about "breaking" for the time being of the circular symptomatology enabled lithium to exhibit its normothymic stabilizing activity to a greater degree as compared to carbamazepine.
为了打破持续性精神病，对20例患有情感性和分裂情感性精神病的患者进行了电休克治疗（每天或隔天5至10次），这些患者每年至少经历3个情感周期，并且对碳酸锂或卡马西平预防性治疗耐药，条件是这些药物持续使用一年。电休克治疗完成后，恢复之前进行的预防性治疗。结果发现，一年中情感症状的总持续时间平均值以及一年中所见情感发作的平均次数大幅下降。8例患者实现了持续性精神病的完全“打破”，形成了持续不少于5至6个月的稳定缓解，其中包括8例有“快速循环”现象的患者中的3例。电休克治疗的打破效果在没有有机中枢神经系统衰竭迹象、病程较短且持续性疾病本身病程较短的患者中更有可能出现，并且在发作之间有明确的缓解、抑郁周期比躁狂周期更占优势且强度更大的情况下也更有可能出现。与卡马西平相比，电休克治疗暂时打破循环症状的同时，能使锂更大程度地发挥其心境正常化稳定活性。
