Sakaguchi H, Yoshimura H, Nishimura Y, Iwata K, Ohishi H, Uchida H
Dept. of Oncoradiology, Nara Medical University.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1725-30.
The behavior of an anti-cancer drug consisting of transcatheter hepatic segmental arterial chemoembolization using Lipiodol mixed with an anti-cancer drug followed by gelatin sponge (segmental Lp-TAE: Seg-Lp-TAE) was assessed in comparison to that of the non-segmental Lp-TAE to whole liver (Lp-TAE) by means of Tc-99m pertechnetate (RI). Injection of Lipiodol mixed with Adriamycin and 740 mBq of RI followed by gelatin sponge was carried out from segmental or subsegmental hepatic artery in 12 cases of hepatocellular carcinoma and from proper or right hepatic artery in 11 cases (9 with hepatocellular carcinoma and 2 with metastatic liver tumor). The distribution and retention of RI were studied from the time activity curves of ROIs in tumor and non-tumor area, and scintigrams at 4 and 24 hours after injection. The integral value ratio of tumor to non-tumor was significantly higher in Seg-Lp-TAE, indicating that es the distribution of RI after Seg-Lp-TAE is selective in the segments where tumor exists. In Seg-Lp-TAE, the T1/2 was higher and the count ratio of tumor to non-tumor was significantly higher at 4 hours and even higher at 24 hours after injection. These results suggest that an anti-cancer drug reinforces the effect on tumor with little adverse effect on normal liver in Seg-Lp-TAE, which is more advantageous to the treatment of hepatocellular carcinoma.
通过锝-99m高锝酸盐（RI）评估了一种抗癌药物的行为，该药物由使用与抗癌药物混合的碘油进行经导管肝段动脉化疗栓塞，随后使用明胶海绵（段性碘油-经动脉化疗栓塞：Seg-Lp-TAE）组成，并与非段性全肝碘油-经动脉化疗栓塞（Lp-TAE）进行比较。在12例肝细胞癌患者中，从肝段或亚肝段动脉注射与阿霉素混合的碘油和740 mBq的RI，随后注入明胶海绵；在11例患者（9例肝细胞癌和2例肝转移瘤）中，从肝固有动脉或肝右动脉进行注射。通过肿瘤和非肿瘤区域感兴趣区的时间-活度曲线以及注射后4小时和24小时的闪烁扫描图，研究了RI的分布和滞留情况。Seg-Lp-TAE中肿瘤与非肿瘤的积分值比显著更高，表明Seg-Lp-TAE后RI的分布在肿瘤所在段具有选择性。在Seg-Lp-TAE中，T1/2更高，注射后4小时肿瘤与非肿瘤的计数比显著更高，24小时时甚至更高。这些结果表明，在Seg-Lp-TAE中，抗癌药物增强了对肿瘤的作用，对正常肝脏的不良反应较小，这对肝细胞癌的治疗更有利。
