发现了一系列新型非酸性苯并呋喃 EP1 受体拮抗剂。
Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
机构信息
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom.
出版信息
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4343-8. doi: 10.1016/j.bmcl.2011.05.047. Epub 2011 May 23.
PMID:21676612
Abstract
We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.
摘要
我们描述了一系列新型苯并呋喃 EP（1）拮抗剂的发现和优化，从而鉴定出 26d，这是一种新型非酸性 EP（1）拮抗剂，在慢性炎症性疼痛的临床前模型中显示出疗效。
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