Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
Angiology. 2012 Apr;63(3):184-93. doi: 10.1177/0003319711410226. Epub 2011 Jun 15.
Many statin-treated patients are not achieving treatment goals and are at risk of cardiovascular (CV) disease. We report the results of patients enrolled in an observational study in Greece, which estimated the residual lipid abnormalities in statin-treated patients. Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglyceride concentrations were recorded in patients receiving statin therapy for ≥ 3 months, classified by CV risk according to European Society of Cardiology guidelines. Sixty-three percent of statin-treated patients had an LDL-c not at goal. Low-risk patients were more likely to have an LDL-c not at goal compared with high-risk patients (67.3% vs 61.0%, respectively). They were also less likely to have low HDL-c levels and elevated triglyceride levels compared with high-risk patients. Smoking and sedentary lifestyle were not associated with dyslipidemia in this population. Approximately two thirds of statin-treated patients in Greece are not reaching target/normal lipid levels and could benefit from improved lipid management.
许多接受他汀类药物治疗的患者未达到治疗目标，存在心血管（CV）疾病风险。我们报告了在希腊进行的一项观察性研究中入组患者的结果，该研究评估了接受他汀类药物治疗的患者的残余脂质异常情况。在接受他汀类药物治疗≥3 个月的患者中记录了低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯浓度，并根据欧洲心脏病学会指南按 CV 风险进行分类。63%的接受他汀类药物治疗的患者 LDL-c 未达标。与高危患者相比，低危患者 LDL-c 不达标的可能性更高（分别为 67.3%和 61.0%）。与高危患者相比，他们的 HDL-c 水平较低和甘油三酯水平升高的可能性也较低。在该人群中，吸烟和久坐的生活方式与血脂异常无关。大约三分之二的希腊接受他汀类药物治疗的患者未达到目标/正常血脂水平，可能受益于改善的血脂管理。
