Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Angiology. 2012 Apr;63(3):218-22. doi: 10.1177/0003319711411291. Epub 2011 Jun 15.
Prospective studies and clinical trials have shown that C-reactive protein (CRP) independently predicts the occurrence of cardiovascular events, even in individuals without hypercholesterolemia. We evaluated whether CRP can predict the severity of coronary artery stenosis in patients with lower low-density lipoprotein cholesterol (LDL-C) levels. A total of 418 patients with lower LDL-C (<3.37 mmol/L) who underwent coronary angiography were recruited. The median levels of CRP increased according to the number of stenotic vessels. Multivariable adjustment model indicated that CRP was associated with the severity of coronary artery disease (CAD) in the top to the bottom third comparison of CRP levels, yielding an odds ratio of 1.72 (95% confidence interval: 1.08-2.74); this trend was preserved after excluding the confounding effect of statin treatment. C-reactive protein may serve as a useful biomarker for improving the risk assessment and secondary prevention of CAD patients without hypercholesterolemia.
前瞻性研究和临床试验表明，C 反应蛋白（CRP）可独立预测心血管事件的发生，即使在没有高胆固醇血症的人群中也是如此。我们评估了 CRP 是否可以预测 LDL-C 水平较低的患者的冠状动脉狭窄严重程度。共招募了 418 名 LDL-C 较低（<3.37mmol/L）的接受冠状动脉造影的患者。根据狭窄血管的数量，CRP 的中位数水平升高。多变量调整模型表明，CRP 与冠状动脉疾病（CAD）的严重程度相关，在 CRP 水平从上到下的三分之一比较中，比值比为 1.72（95%置信区间：1.08-2.74）；在排除他汀类药物治疗的混杂影响后，这种趋势仍然存在。CRP 可能是一种有用的生物标志物，可用于改善无高胆固醇血症的 CAD 患者的风险评估和二级预防。
