DDAH says NO to ADMA.
作者信息
Cooke John P, Ghebremariam Yohannes T
出版信息
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1462-4. doi: 10.1161/ATVBAHA.111.228833.
Abstract
摘要
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本文引用的文献
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Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.二甲基精氨酸二甲氨基水解酶-1 是降解心血管风险因子不对称二甲基精氨酸的关键酶。
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6. doi: 10.1161/ATVBAHA.110.222638. Epub 2011 Apr 14.
2
Dietary nitrate, nitric oxide, and restenosis.饮食硝酸盐、一氧化氮与再狭窄。
J Clin Invest. 2011 Apr;121(4):1258-60. doi: 10.1172/JCI57193. Epub 2011 Mar 23.
3
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt.二甲基精氨酸二甲胺水解酶 1 通过一氧化氮和 Akt 调节血管内皮细胞生长。
Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):890-7. doi: 10.1161/ATVBAHA.110.215640. Epub 2011 Jan 6.
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Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.不对称二甲基精氨酸与外周动脉疾病患者疾病严重程度、主要不良心血管事件和全因死亡率的评估指标相关。
Vasc Med. 2010 Aug;15(4):267-74. doi: 10.1177/1358863X10364552. Epub 2010 May 19.
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Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.精氨酸二甲胺水解酶过表达通过降低非对称性二甲基精氨酸改善载脂蛋白 E 缺陷小鼠的动脉粥样硬化。
Am J Pathol. 2010 May;176(5):2559-70. doi: 10.2353/ajpath.2010.090614. Epub 2010 Mar 26.
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Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.腺病毒介导的 DDAH 过表达改善血管张力调节。
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Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.血管内皮特异性二甲基精氨酸二甲氨基水解酶-1 缺陷小鼠揭示血管内皮在去除非对称性二甲基精氨酸中发挥重要作用。
Circulation. 2009 Dec 1;120(22):2222-9. doi: 10.1161/CIRCULATIONAHA.108.819912. Epub 2009 Nov 16.
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Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production.二甲基精氨酸二甲氨基水解酶在调节内皮细胞一氧化氮产生中的作用。
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J Pharmacol Exp Ther. 2009 Oct;331(1):234-43. doi: 10.1124/jpet.109.153510. Epub 2009 Jul 15.
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