Nukui Akinori, Morita Tatsuo
Dept. of Urology, Jichi Medical University.
Gan To Kagaku Ryoho. 2011 Jun;38(6):967-72.
The objective of this study was to assess the usefulness of ice cubes and vapocoolant spray for relieving pain induced by goserelin acetate injections.
Fourty-seven patients with prostate cancer receiving hormonal manipulation by goserelin acetate were enrolled in this study. They received goserelin acetate injections after analgesic pretreatments with ice cubes until March 2009, and with vapocoolant spray and ethyl chroride after April 2009. We had them fill out a questionnaire asking whether they preferred to continue cooling pretreatments. We assessed the pricking pain using the face scale(FS)and the numerical rating scale(NRS).
The median FS and NRS scores at the first pretreatment(ice cube or vapocoolant spray)were lower than those at no pretreatment(p<0. 01 in both scores). Thirty-nine patients(83. 0%)preferred cooling pretreatment. Only 5 patients preferred no pretreatment. The differences in the median FS score and NRS score between ice cubes and vapocoolant spray were not significant(p=0. 353 in FS, p=0. 120 in NRS). No adverse events associated with the cooling pretreatment occurred except for late-onset subcutaneous hemorrhages in 2 cases.
The local cooling at the injection site of goserelin acetate was effective irrespective of the method(ice cube or vapocoolant spray)for the relief of pricking pain without causing serious complications.
本研究的目的是评估冰块和挥发性冷却剂喷雾对缓解醋酸戈舍瑞林注射所致疼痛的有效性。
47例接受醋酸戈舍瑞林激素治疗的前列腺癌患者纳入本研究。在2009年3月之前，他们在使用冰块进行镇痛预处理后接受醋酸戈舍瑞林注射，2009年4月之后则使用挥发性冷却剂喷雾和氯乙烷进行预处理。我们让他们填写一份问卷，询问他们是否愿意继续进行冷却预处理。我们使用面部表情量表（FS）和数字评定量表（NRS）评估刺痛疼痛。
首次预处理（冰块或挥发性冷却剂喷雾）时的FS和NRS评分中位数低于未进行预处理时（两项评分均p<0.01）。39例患者（83.0%）更喜欢冷却预处理。只有5例患者更喜欢不进行预处理。冰块和挥发性冷却剂喷雾之间的FS评分中位数和NRS评分差异不显著（FS中p=0.353，NRS中p=0.120）。除2例迟发性皮下出血外，未发生与冷却预处理相关的不良事件。
醋酸戈舍瑞林注射部位的局部冷却无论采用何种方法（冰块或挥发性冷却剂喷雾），均可有效缓解刺痛疼痛，且不会引起严重并发症。
