Ikeda Katsumi, Ogawa Yoshinori, Nagahara Hisashi, Xiang Zhang, Sakurai Katsunobu, Fukuoka Tatsunari, Tokunaga Shinya, Nishiguchi Yukio
Dept. of Breast Surgical Oncology, Osaka City General Hospital.
Gan To Kagaku Ryoho. 2010 Feb;37(2):291-3.
LH-RH agonist is the key drug in hormonal therapy for premenopausal patients with breast cancer. It is important to reduce the pain related to injecting the LH-RH agonist, because patients must continue the medication for several years. We developed a way to reduce the pain by cooling the needle injecting site with a frozen ice pack. 18 premenopausal postoperated women filled out a questionnaire on the severity of pain upon injecting Goserelin acetate compared with the pain without this cooling method and pretreatment. We estimated the pain by a Numerical Rating Scale(NRS). The NRS scores of this cooling method revealed the pain to be significantly less than by control method(p<0. 005). This cooling method could be useful for the reduction of pain upon injecting the LH-RH agonist.
促黄体生成素释放激素（LH-RH）激动剂是绝经前乳腺癌患者激素治疗的关键药物。减轻注射LH-RH激动剂带来的疼痛很重要，因为患者必须持续用药数年。我们开发了一种通过用冷冻冰袋冷却注射部位来减轻疼痛的方法。18名绝经前术后女性填写了一份问卷，比较了使用这种冷却方法和未进行预处理时注射醋酸戈舍瑞林的疼痛严重程度。我们通过数字评分量表（NRS）评估疼痛程度。这种冷却方法的NRS评分显示疼痛明显低于对照方法（p<0.005）。这种冷却方法可能有助于减轻注射LH-RH激动剂时的疼痛。
