[1例胃癌多发骨转移伴弥散性血管内凝血经S-1与低剂量顺铂联合治疗成功控制的病例]
[A case of multiple bone metastasis of gastric carcinoma accompanying DIC successfully controlled with combination of S-1 and low-dose CDDP].
作者信息
Nishida Takahiro, Nakano Shigeharu, Shida Takashi, Ootsuka Tomonori, Ogasawara Takeshi, Takahashi Makoto
机构信息
Dept. of Surgery, Social Insurance Funabashi Central Hospital.
出版信息
Gan To Kagaku Ryoho. 2011 Jun;38(6):1039-41.
The patient was a 50-year-old man who underwent total gastrectomy twelve years ago. Ahigh level of ALP was found in the patient in April 2008. Based on various examinations, the diagnosis of multiple bone metastasis of gastric carcinoma accompanying disseminated intravascular coagulation(DIC)was made. The patient was treated with S-1/CDDP. S-1(80mg/ m / / 2day)was administered for 14 days followed by a 7-day rest period, and a CDDP(20mg/m2)infusion was administered on days 1 and 8. After one course of treatment, the DIC was controlled, and the patient was given a one-year prognosis. The combination of S-1 and low-dose CDDP may be considered effective even for multiple bone metastases of gastric carcinoma with DIC.
该患者为一名50岁男性，12年前接受了全胃切除术。2008年4月在该患者体内发现碱性磷酸酶（ALP）水平较高。基于各项检查，诊断为胃癌多发骨转移伴弥散性血管内凝血（DIC）。患者接受了S-1/顺铂治疗。S-1（80mg/m²/2天）给药14天，随后休息7天，顺铂（20mg/m²）于第1天和第8天进行静脉输注。经过一个疗程的治疗，DIC得到控制，患者获得了一年的预后。S-1与低剂量顺铂联合使用即使对于伴有DIC的胃癌多发骨转移可能也被认为是有效的。
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