Zhao Q
Zhonghua Yi Xue Za Zhi. 1990 Apr;70(4):191-4, 14.
In this paper are reported the results of a systematic study of chemotactic effect and other features of the regeneration of severed peripheral nerve in rat. The results revealed that (1) the proximal stumps of tibial and peroneal nerves tended to grow to their original distal stumps, (2) motor branch and sensory branch also showed preferential growth to the homojunctional patterns of nerve grafts, (3) using muscle and skin as targets, these not only attracted nerve growth, out also selectively attracted motor branch and sensory branch. Our results indicate that during rat peripheral nerve regeneration there exists neurotropism as evidenced by tissue specificity, topographic specificity, functional pattern specificity and target specificity. Based on these findings, the possible mechanism of neurochemotropism is discussed. Distance between the stumps, selective use of experimental chamber material and the clinical significance of this neurotropic research are also discussed.
本文报道了对大鼠切断的周围神经再生的趋化作用及其他特征进行系统研究的结果。结果表明：（1）胫神经和腓总神经的近端残端倾向于向其原来的远端残端生长；（2）运动支和感觉支也表现出向神经移植的同型连接模式优先生长；（3）以肌肉和皮肤为靶标，它们不仅吸引神经生长，而且还选择性地吸引运动支和感觉支。我们的结果表明，在大鼠周围神经再生过程中存在神经趋向性，表现为组织特异性、局部解剖特异性、功能模式特异性和靶标特异性。基于这些发现，讨论了神经化学趋向性的可能机制。还讨论了残端之间的距离、实验腔材料的选择性使用以及这种神经趋向性研究的临床意义。
