使用富含胞嘧啶的发夹 DNA 进行 pH 控制的可逆药物结合和释放。
pH-controlled reversible drug binding and release using a cytosine-rich hairpin DNA.
机构信息
Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun, Jilin 130022, China.
出版信息
Chem Commun (Camb). 2011 Jul 28;47(28):8043-5. doi: 10.1039/c1cc12594j. Epub 2011 Jun 16.
PMID:21677978
Abstract
Here we report that a cytosine-rich DNA carrier, that oscillates between a hairpin and an i-motif structure in its response to pH variation, can be used as a drug binding and release device.
摘要
在这里，我们报告了一种富含胞嘧啶的 DNA 载体，它在响应 pH 值变化时在发夹和 i 型结构之间振荡，可以用作药物结合和释放装置。
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