Department of Chemistry, Banaras Hindu University, Varanasi, India.
J Enzyme Inhib Med Chem. 2012 Jun;27(3):319-29. doi: 10.3109/14756366.2011.588228. Epub 2011 Jun 16.
Cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes with two new unsymmetrical ligands, isatin salicylaldehyde oxalic acid dihydrazide (isodh) and isatin salicylaldehyde malonic acid dihydrazide (ismdh) were synthesized and characterized by elemental analyses, electrical conductance, magnetic moments, electronic, NMR, ESR and IR spectral studies. The isodh acts as a dibasic tetra dentate ligand bonding through two >C=N-, a deprotonated phenolate and deprotonated indole enolate groups to the metal. The ismdh ligand shows monobasic tetra dentate behaviour in bonding with metal ion through two >C=N-, indole >C=O and a deprotonated phenolate group. The electronic spectral data suggest 4-coordinate square planar geometry for Co(II), Ni(II) and Cu(II) complexes of isodh, whereas, 6-coordinate octahedral structure for the ismdh complexes. The ESR studies also indicate a square planar and distorted octahedral environment around Cu(II) for isodh and ismdh complexes, respectively. Most of the metal complexes show better antifungal activity than the standard and a significant antibacterial activity against various fungi and bacteria.
钴(II)、镍(II)、铜(II)、锌(II)和镉(II)与两个新的不对称配体，即靛红水杨醛草酸二酰肼（isodh）和靛红水杨醛丙二酸二酰肼（ismdh）的配合物被合成并通过元素分析、电导率、磁矩、电子、NMR、ESR 和 IR 光谱研究进行了表征。isodh 作为二齿四配位配体，通过两个>C=N-、一个去质子化的苯氧基团和去质子化的吲哚烯醇基团与金属结合。ismdh 配体通过两个>C=N-、吲哚>C=O 和一个去质子化的苯氧基团与金属离子表现出单齿四配位行为。电子光谱数据表明，isodh 的 Co(II)、Ni(II)和 Cu(II)配合物具有 4 配位的平面四方几何构型，而 ismdh 配合物则具有 6 配位的八面体结构。ESR 研究也表明，isodh 和 ismdh 配合物中 Cu(II)周围分别具有平面四方和扭曲八面体环境。大多数金属配合物表现出比标准更好的抗真菌活性，并且对各种真菌和细菌具有显著的抗菌活性。
