Department of Dermatology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.
Clin Exp Dermatol. 2011 Jul;36(5):473-8. doi: 10.1111/j.1365-2230.2010.03988.x.
Hyperuricaemia is a common finding in patients with psoriasis. However, previous studies have reported inconsistent results about the association between serum uric acid concentration (SUAC) and psoriasis severity. Recent studies have also reported that SUAC is associated with metabolic dysregulation.
To assess any association between SUAC and clinical features of psoriasis, and to investigate the characteristics of patients with psoriasis with hyperuricaemia compared with similar patients with normouricaemia.
Cross-sectional data from 198 Korean patients with psoriasis who visited our clinic were analysed. Association of SUAC with clinical features of psoriasis, body mass index (BMI) and various laboratory values was assessed in both genders separately.
The average uric acid concentration of patients with psoriasis was not significantly different from that of the healthy population, for both genders (P > 0.05). There was a positive correlation between SUAC and Psoriasis Area and Severity Index (PASI) and BMI in patients with psoriasis (P < 0.05). There was no association with age of disease onset, family history of psoriasis, or other laboratory values (P > 0.05), in either gender. Of the other factors of disease severity, the extent of body surface involvement was correlated with uric acid concentration (P < 0.05) although there was no significant relationship with activity of individual lesions (P > 0.05). Mean PASI and extent of psoriasis were increased in hyperuricaemic compared with normouricaemic patients (P < 0.05).
SUAC in patients with psoriasis is positively associated with PASI, extent of skin involvement and BMI for both genders independently.
高尿酸血症是银屑病患者的常见表现。然而，既往研究关于血尿酸浓度（SUAC）与银屑病严重程度之间的相关性得出的结果并不一致。最近的研究还报告称，SUAC 与代谢失调有关。
评估 SUAC 与银屑病临床特征之间的任何关联，并研究高尿酸血症患者与血尿酸正常患者相比的特征。
分析了 198 名就诊于我院的韩国银屑病患者的横断面数据。分别在男性和女性中评估 SUAC 与银屑病的临床特征、体重指数（BMI）和各种实验室值之间的关联。
银屑病患者的平均尿酸浓度与男性和女性的健康人群相比无显著差异（P > 0.05）。在银屑病患者中，SUAC 与银屑病面积和严重程度指数（PASI）和 BMI 呈正相关（P < 0.05）。与发病年龄、银屑病家族史或其他实验室值无相关性（P > 0.05），在男性和女性中均如此。在疾病严重程度的其他因素中，尽管与单个皮损的活动度无显著关系（P > 0.05），但身体表面积受累程度与尿酸浓度相关（P < 0.05）。与血尿酸正常的患者相比，高尿酸血症患者的平均 PASI 和银屑病严重程度增加（P < 0.05）。
SUAC 与 PASI、皮肤受累程度和 BMI 独立相关，与性别无关。
