Institute of Pathology, HELIOS Klinikum Emil von Behring, Berlin, Germany.
Diagn Pathol. 2011 Jun 16;6:53. doi: 10.1186/1746-1596-6-53.
The recent introduction of bronchoscopically recovered cryobiopsy of lung tissue has opened up new possibilities in the diagnosis of neoplastic and non-neoplastic lung diseases in various aspects. Most notably the morphological diagnosis of peripheral lung biopsies promises to achieve a better yield with a high quality of specimens. To better understand this phenomenon, its diagnostic options and perspectives, this study morphometrically compares 15 cryobiopsies and 18 transbronchial forceps biopsies of peripheral lung tissue a priori without considering clinical hit ratio or integration of results in the clinical diagnostic processing. Cryotechnically harvested specimens were significantly larger (mean: 17.1 ± 10.7 mm2 versus 3.8 ± 4.0 mm2) and contained alveolar tissue more often. If present, the alveolar part in cryobiopsies exceeded the one of forceps biopsies. The alveolar tissue of crybiopsy specimens did not show any artefacts. Based on these results cryotechnique seems to open up new perspectives in bronchoscopic diagnosis of lung disease.
最近引入的支气管镜下回收冷冻活检技术在肿瘤和非肿瘤性肺部疾病的诊断方面开辟了新的可能性。最值得注意的是，外围肺活检的形态学诊断有望通过高质量的标本获得更好的效果。为了更好地理解这一现象，及其诊断选择和前景，本研究对 15 例冷冻活检和 18 例经支气管钳活检的外围肺组织进行了形态计量学比较，这些活检组织在临床诊断处理中，事先没有考虑临床阳性率或结果的整合。冷冻技术采集的标本明显更大（平均值：17.1 ± 10.7 mm2 比 3.8 ± 4.0 mm2），且更常包含肺泡组织。如果存在，冷冻活检中的肺泡部分超过了钳活检。冷冻活检标本的肺泡组织没有任何人为假象。基于这些结果，冷冻技术似乎为肺部疾病的支气管镜诊断开辟了新的前景。
