Kreisig T, Pickardt C R, Horn K, Bechtner G, Vaitl C, Kirsch C M, Knesewitsch P
Abteilung der Radiologischen Klinik, Ludwig-Maximilians-Universität, München, BRD.
Nuklearmedizin. 1990 Jun;29(3):113-9.
Global TcTU was determined in 568 patients without any specific thyroid drug intake--54 with normal thyroid, 274 with goitre and euthyroidism and 240 with thyroid autonomy. 57 patients with autonomy and overt hyperthyroidism were the only group with TcTU values significantly higher than normals. Common to all groups was a large scatter of the TcTU values. In 332, the effects of individual iodine supply were studied by measuring the iodine concentration in spot urine samples. There was a significant inverse correlation between the TcTU values and the urinary iodine excretion in the groups of normal thyroids and of goitres with euthyroidism. In the group with autonomy an effect of iodine supply could only be seen in cases of greatly increased urinary iodine excretion, resulting in very low TcTU values. Out of 20 patients with autonomy and iodine contamination, only 4 showed overt hyperthyroidism. The large scatter of TcTU values in all groups may be explained by the persistent iodine deficiency as well as by the frequent exposure to unknown amounts of iodine in patients with thyroid disease. Therefore, the spontaneous TcTU alone cannot identify a small group of patients with autonomy and high risk of iodine-induced hyperthyroidism, from a very large group of patients with goitre.
对568例未服用任何特定甲状腺药物的患者测定了总体甲状腺摄取率（TcTU）——54例甲状腺功能正常，274例甲状腺肿且甲状腺功能正常，240例甲状腺自主性。57例自主性且显性甲状腺功能亢进的患者是唯一一组TcTU值显著高于正常的人群。所有组的共同特点是TcTU值离散度大。在332例患者中，通过测定随机尿样中的碘浓度研究了个体碘供应的影响。正常甲状腺组和甲状腺肿且甲状腺功能正常组的TcTU值与尿碘排泄之间存在显著负相关。在自主性组中，仅在尿碘排泄大幅增加导致TcTU值极低的情况下才能观察到碘供应的影响。在20例自主性且碘污染的患者中，只有4例表现为显性甲状腺功能亢进。所有组中TcTU值的大离散度可能是由于持续碘缺乏以及甲状腺疾病患者频繁接触未知量碘所致。因此，仅靠自发的TcTU无法从大量甲状腺肿患者中识别出一小部分具有自主性且碘诱发甲状腺功能亢进风险高的患者。
