Ysrael M C, Croft K D
Research Centre for Natural Sciences, University of Santo Tomas, Manila, Philippines.
Planta Med. 1990 Jun;56(3):268-70. doi: 10.1055/s-2006-960953.
The sesquiterpene lactone scandenolide, isolated from the Philippines medicinal plant Mikania cordata, at a dose of 100 microM completely inhibited whole blood chemiluminescence in response to the activators PMA and zymosan. In isolated inflammatory rat leukocytes this compound inhibited both leukotriene B4 and 5-HETE production with IC50 of 15 microM and 30 microM, respectively. The formation of the cyclooxygenase product thromboxane B2 was not inhibited in the concentration range 10 to 200 microM of scandenolide. The formation of the potent inflammatory mediator platelet activating factor (PAF) was suppressed by microM concentrations of scandenolide with an IC50 of less than 20 microM. The presence of a compound in M. cordata which inhibits some of the inflammatory mediators such as leukotrienes and PAF may explain at least in part some of its medicinal properties.
从菲律宾药用植物光叶藤菊中分离出的倍半萜内酯 scandenoide，剂量为 100 微摩尔时，可完全抑制全血对激活剂佛波酯（PMA）和酵母聚糖的化学发光反应。在分离的炎症大鼠白细胞中，该化合物抑制白三烯 B4 和 5-羟二十碳四烯酸（5-HETE）的产生，其半数抑制浓度（IC50）分别为 15 微摩尔和 30 微摩尔。在 10 至 200 微摩尔的 scandenoide 浓度范围内，环氧合酶产物血栓素 B2 的形成未受抑制。微摩尔浓度的 scandenoide 可抑制强效炎症介质血小板活化因子（PAF）的形成，其 IC50 小于 20 微摩尔。光叶藤菊中存在一种抑制某些炎症介质（如白三烯和 PAF）的化合物，这可能至少部分解释了其一些药用特性。
