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Role of glutamine in cancer: therapeutic and imaging implications.谷氨酰胺在癌症中的作用：治疗和成像意义。
J Nucl Med. 2011 Jul;52(7):1005-8. doi: 10.2967/jnumed.110.084244. Epub 2011 Jun 16.
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Metabolic Imaging of Glutamine in Cancer.癌症中谷氨酰胺的代谢成像
J Nucl Med. 2017 Apr;58(4):533-537. doi: 10.2967/jnumed.116.182345. Epub 2017 Feb 23.
3
Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.癌症中的代谢重编程：解析谷氨酰胺在肿瘤发生中的作用。
Semin Cell Dev Biol. 2012 Jun;23(4):362-9. doi: 10.1016/j.semcdb.2012.02.002. Epub 2012 Feb 11.
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Glutamine and cancer: cell biology, physiology, and clinical opportunities.谷氨酰胺与癌症：细胞生物学、生理学和临床机遇。
J Clin Invest. 2013 Sep;123(9):3678-84. doi: 10.1172/JCI69600. Epub 2013 Sep 3.
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Therapeutic strategies impacting cancer cell glutamine metabolism.影响癌细胞谷氨酰胺代谢的治疗策略。
Future Med Chem. 2013 Sep;5(14):1685-700. doi: 10.4155/fmc.13.130.
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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.Q 的下一个问题是：谷氨酰胺在代谢、细胞生物学和癌症中的多种功能。
Oncogene. 2010 Jan 21;29(3):313-24. doi: 10.1038/onc.2009.358. Epub 2009 Nov 2.
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Glutamine Metabolism in Cancer: Understanding the Heterogeneity.癌症中的谷氨酰胺代谢：理解异质性
Trends Cancer. 2017 Mar;3(3):169-180. doi: 10.1016/j.trecan.2017.01.005.
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PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.正电子发射断层扫描（PET）成像通过 18F-(2S,4R)4-氟谷氨酸探测肿瘤中的谷氨酰胺分解代谢。
J Nucl Med. 2011 Dec;52(12):1947-55. doi: 10.2967/jnumed.111.093815. Epub 2011 Nov 15.
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Glutaminolysis: A Hallmark of Cancer Metabolism.谷氨酰胺分解：癌症代谢的一个标志
Annu Rev Biomed Eng. 2017 Jun 21;19:163-194. doi: 10.1146/annurev-bioeng-071516-044546. Epub 2017 Mar 8.
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Metabolic alterations in bladder cancer: applications for cancer imaging.膀胱癌的代谢改变：在癌症成像中的应用
Exp Cell Res. 2016 Feb 1;341(1):77-83. doi: 10.1016/j.yexcr.2016.01.005. Epub 2016 Jan 22.
引用本文的文献
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Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI.使用化学交换饱和转移磁共振成像（CEST MRI）对前列腺肿瘤模型中谷氨酰胺的摄取和代谢进行成像。
Npj Imaging. 2025 Aug 1;3(1):34. doi: 10.1038/s44303-025-00100-3.
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Reproducibility and repeatability of 18F-(2S, 4R)-4-fluoroglutamine PET imaging in preclinical oncology models.18F-(2S, 4R)-4-氟谷氨酰胺PET成像在临床前肿瘤模型中的可重复性和再现性
PLoS One. 2025 Jan 9;20(1):e0313123. doi: 10.1371/journal.pone.0313123. eCollection 2025.
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Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.色氨酸通过吲哚 3-丙酮酸合成促进 MYC 依赖性肝肿瘤发生。
Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3.
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Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment.利用癌症的阿喀琉斯之踵：破坏谷氨酰胺代谢以实现有效的癌症治疗。
Front Pharmacol. 2024 Mar 6;15:1345522. doi: 10.3389/fphar.2024.1345522. eCollection 2024.
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MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma.GLS1和NAMPT中MYC的依赖性是多发性骨髓瘤的一种治疗弱点。
iScience. 2024 Mar 4;27(4):109417. doi: 10.1016/j.isci.2024.109417. eCollection 2024 Apr 19.
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Glutamine Deprivation Synergizes the Anticancer Effects of Cold Atmospheric Plasma on Esophageal Cancer Cells.谷氨酰胺剥夺可增强冷等离体等离子体对食管癌的抗癌作用。
Molecules. 2023 Feb 2;28(3):1461. doi: 10.3390/molecules28031461.
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Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines.CB-839抑制胶质母细胞瘤细胞系中的谷氨酰胺酶后的代谢调整
Cancers (Basel). 2023 Jan 15;15(2):531. doi: 10.3390/cancers15020531.
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Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2,4)-4-F-Fluoroglutamine.利用正电子发射断层扫描示踪剂（2,4）-4-F-氟谷氨酸探测动脉粥样硬化病灶中的谷氨酰胺代谢。
Front Immunol. 2022 Jan 25;13:821423. doi: 10.3389/fimmu.2022.821423. eCollection 2022.
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Regulation of Nuclear Factor-kappaB Function by -GlcNAcylation in Inflammation and Cancer.炎症与癌症中O-连接N-乙酰葡糖胺化对核因子-κB功能的调控
Front Cell Dev Biol. 2021 Oct 15;9:751761. doi: 10.3389/fcell.2021.751761. eCollection 2021.
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Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias.急性和慢性髓系白血病中的氨基酸代谢脆弱性
Front Oncol. 2021 Jul 1;11:694526. doi: 10.3389/fonc.2021.694526. eCollection 2021.
本文引用的文献
1
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.通过成像技术分析癌症代谢：向临床研究转化的前景。
Neoplasia. 2011 Feb;13(2):81-97. doi: 10.1593/neo.101102.
2
Metabolic positron emission tomography imaging in cancer detection and therapy response.癌症检测和治疗反应中的代谢正电子发射断层成像。
Semin Oncol. 2011 Feb;38(1):55-69. doi: 10.1053/j.seminoncol.2010.11.012.
3
C11-acetate and F-18 FDG PET for men with prostate cancer bone metastases: relative findings and response to therapy.前列腺癌骨转移男性患者的 C11-醋酸盐和 F-18 FDG PET：相对发现和治疗反应。
Clin Nucl Med. 2011 Mar;36(3):192-8. doi: 10.1097/RLU.0b013e318208f140.
4
Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors.合成光学纯 4-氟-谷氨酸作为肿瘤潜在代谢成像剂。
J Am Chem Soc. 2011 Feb 2;133(4):1122-33. doi: 10.1021/ja109203d. Epub 2010 Dec 29.
5
4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.4-[18F]氟谷氨酸（BAY 85-8050），一种用于肿瘤 PET 成像的新型氨基酸放射性示踪剂：合成与体外特性。
J Med Chem. 2011 Jan 13;54(1):406-10. doi: 10.1021/jm101068q. Epub 2010 Dec 3.
6
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.癌基因和抑癌基因对代谢开关的控制。
Science. 2010 Dec 3;330(6009):1340-4. doi: 10.1126/science.1193494.
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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.己糖胺生物合成途径将生长因子诱导的谷氨酰胺摄取与葡萄糖代谢偶联。
Genes Dev. 2010 Dec 15;24(24):2784-99. doi: 10.1101/gad.1985910. Epub 2010 Nov 24.
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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.抑制谷氨酰胺酶优先减缓携带 IDH1 突变的神经胶质瘤细胞的生长。
Cancer Res. 2010 Nov 15;70(22):8981-7. doi: 10.1158/0008-5472.CAN-10-1666. Epub 2010 Nov 2.
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Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7T.通过优化 7T 下的（1）H MRS 提高脑偶联代谢物的分辨率。
NMR Biomed. 2010 Nov;23(9):1044-52. doi: 10.1002/nbm.1529.
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Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells.氮的同化作用是谷氨酰胺分解在增殖细胞中的重要性的基础。
Cell Cycle. 2010 Oct 1;9(19):3921-32. doi: 10.4161/cc.9.19.13139. Epub 2010 Oct 25.
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