Schröder H C, Steffen R, Ugarković D, Zahn R K, Müller W E
Institut für Physiologische Chemie, Mainz.
Z Gerontol. 1990 May-Jun;23(3):117-22.
In the present work, we show that the activity of DNA topoisomerase II in quail oviduct nuclei significantly increases with age. Posttranslational modifications of the nuclear-matrix-associated enzyme by matrix-bound poly(ADP-ribose) synthetase and protein kinase, whose activities change with age, are demonstrated and offer possible mechanisms by which the age-dependent change in enzyme activity may be caused. It is assumed that the age-correlated enhancement of DNA-topoisomerase-II activity may cause changes in the topological state of DNA, with possible consequences for DNA replication, transcription, and repair with age.
