The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.

Protein kinase C epsilon (PKC ɛ) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ɛ in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ɛ functions in vivo, and PKC ɛ has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ɛ on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ɛ could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ɛ signal pathway in the developing brain.