急性镉中毒导致不孕的一种可能机制。

A possible mechanism of infertility by acute cadmium intoxication.

作者信息

Suzuki A, Kajimoto N, Yanagawa T, Sugimoto J, Nagata M

出版信息

J Toxicol Sci. 1978 Nov;3(4):313-23. doi: 10.2131/jts.3.313.

DOI:10.2131/jts.3.313

Abstract

A possible mechanism of infertility by Cd was investigated from the standpoint of influence of Cd on the contractile responses of isolated seminal vesicle from guinea pigs to K, acetylcholine, noradrenaline, Ba and Ca by using the Magnus method. Cd inhibited the contractile responses to the contractile agents tested in a dose-dependent manner. Cd showed the preferential inhibition against the contractile responses to K and Ca. The inhibitory effect of Cd on the contractile responses to noradrenaline and acetylcholine was hardly removed. The effect of Cd was inhibited by the thiol compounds, glutathione and thiola. The active mechanism of Cd was discussed in relation to Ca mobilization.

摘要

从镉对豚鼠离体精囊对钾、乙酰胆碱、去甲肾上腺素、钡和钙的收缩反应的影响的角度出发，采用马格努斯方法研究了镉导致不育的一种可能机制。镉以剂量依赖性方式抑制对所测试收缩剂的收缩反应。镉对钾和钙的收缩反应表现出优先抑制作用。镉对去甲肾上腺素和乙酰胆碱收缩反应的抑制作用几乎无法消除。镉的作用被硫醇化合物、谷胱甘肽和硫普罗宁抑制。结合钙动员讨论了镉的作用机制。

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