Maasilta P K, Rautonen J K, Mattson M T, Mattson K V
Department of Pulmonary Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Eur J Cancer. 1990;26(6):706-8. doi: 10.1016/0277-5379(90)90122-a.
Quality of life was assessed by linear analogue scales for patients with non-small cell lung cancer participating in a phase I-II trial. Chemotherapy consisted of cyclophosphamide 600 mg/m2 intravenously on day 1 and trimetrexate (five dose levels) intravenously on days 1-5, repeated every 21 days. Eleven subjective items were assessed by the patients. Nine of the scales related to performance, problems related to the disease itself and uncertainty about the value of treatment; two scales related to the major known side-effects of chemotherapy. Each patient completed the scales before treatment, on the last day of treatment (day 5) and once between cycles. Variation in the scores for items (e.g. for nausea or appetite) suggests that the method was useful in estimating the patient's perceived quality of life during repeated cycles of chemotherapy. Compliance was good and the method was easily accepted by both patients and nurses as part of a routine.
通过线性模拟量表对参与一项I-II期试验的非小细胞肺癌患者的生活质量进行评估。化疗方案为第1天静脉注射环磷酰胺600mg/m²，第1 - 5天静脉注射三甲曲沙（五个剂量水平），每21天重复一次。患者对11项主观指标进行评估。其中9项量表与身体状况、疾病本身相关问题以及治疗价值的不确定性有关；2项量表与化疗已知的主要副作用有关。每位患者在治疗前、治疗最后一天（第5天）以及两个周期之间各完成一次量表评估。各项指标得分的变化（如恶心或食欲方面）表明该方法有助于评估患者在化疗重复周期中的生活质量感受。依从性良好，该方法作为常规操作的一部分，很容易被患者和护士接受。
