Chang T C, Jap T S, Kwok C F, Won J G, Ho L T
Department of Medicine, Veterans General Hospital-Taipei, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1990 Feb;45(2):83-6.
To examine the effect of steroid therapy on insulin antibody titer in insulin-dependent diabetes mellitus, we studied a 58 year-old gentleman with recurrent diabetic ketoacidosis. No any overt precipitating factors could be accounted for, except limited pancreatic beta cell reserve and high titers of anti insulin antibodies. Despite the persistence of high titers of plasma antiinsulin antibodies, the clinical manifestations of diabetic ketoacidosis improved greatly by the administration of steroid. Nevertheless, the patient still showed the great excursion of plasma glucose concentration.
为研究类固醇疗法对胰岛素依赖型糖尿病患者胰岛素抗体滴度的影响，我们对一名58岁反复发生糖尿病酮症酸中毒的男性患者进行了研究。除了有限的胰岛β细胞储备和高滴度的抗胰岛素抗体外，未发现任何明显的诱发因素。尽管血浆抗胰岛素抗体滴度持续较高，但通过给予类固醇，糖尿病酮症酸中毒的临床表现有了很大改善。然而，患者的血浆葡萄糖浓度仍有较大波动。
