Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA.
Dev Comp Immunol. 2012 Jan;36(1):31-8. doi: 10.1016/j.dci.2011.05.013. Epub 2011 Jun 6.
The secreted globular head C1q (sghC1q) genes can be characterized as a family of genetic loci encoding signal peptides followed by single complement component 1q globular (gC1q) motifs. Members of this family have been referred to as precerebellin-like (Cblnl), C1q-like or ovary specific C1q-like factors, and are transcribed in response to infection and/or during early development. This study was primarily undertaken to identify the zebrafish sghC1q (or DrsghC1q) genes that increase their transcription in response to infection and to examine their transcriptional patterns during early development. Twenty sghC1q genes were found in the zebrafish (Danio rerio) genome (Zv9). Two of the examined twenty genes showed significant up-regulation within 24h of infection with the fish pathogen Streptococcus iniae, and eleven of the examined twenty were expressed during early development. Due to the clustered nature of these genes on chromosomes two and seven, intrachromosomal duplication events are hypothesized and explored.
分泌的球形头部 C1q（sghC1q）基因可被描述为一个家族的遗传基因座，这些基因座编码信号肽，随后是单个补体成分 1q 球形（gC1q）基序。该家族的成员被称为前脑啡肽样（Cblnl）、C1q 样或卵巢特异性 C1q 样因子，并在感染和/或早期发育过程中被转录。本研究主要旨在鉴定斑马鱼 sghC1q（或 DrsghC1q）基因，这些基因在感染时会增加其转录，并研究它们在早期发育过程中的转录模式。在斑马鱼（Danio rerio）基因组（Zv9）中发现了二十个 sghC1q 基因。在所研究的二十个基因中，有两个在感染鱼类病原体鳗弧菌 24 小时内表现出明显的上调，有十一个在早期发育过程中表达。由于这些基因在染色体 2 和 7 上的聚集性质，假设并探讨了染色体内重复事件。
