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Emerging roles for ADAMTS5 during development and disease.

作者信息

Kintakas Christopher, McCulloch Daniel R

机构信息

School of Medicine, Molecular and Medical Research Strategic Research Centre, Deakin University, 75 Pigdons Road, Waurn Ponds, VIC 3216, Australia.

出版信息

Matrix Biol. 2011 Jun;30(5-6):311-7. doi: 10.1016/j.matbio.2011.05.004. Epub 2011 Jun 12.

DOI:10.1016/j.matbio.2011.05.004
PMID:21683141
Abstract
摘要

相似文献

1
Emerging roles for ADAMTS5 during development and disease.ADAMTS5在发育和疾病过程中的新作用。
Matrix Biol. 2011 Jun;30(5-6):311-7. doi: 10.1016/j.matbio.2011.05.004. Epub 2011 Jun 12.
2
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.Adamts5基因编码一种蛋白聚糖降解金属蛋白酶，在小鼠胚胎发育期间及成年组织中由特定细胞谱系表达。
Gene Expr Patterns. 2009 Jun;9(5):314-23. doi: 10.1016/j.gep.2009.02.006. Epub 2009 Feb 27.
3
Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells.ADAMTS5基因的缺失不影响聚集蛋白聚糖或多功能蛋白聚糖的降解，但可促进小鼠脂肪来源基质细胞的葡萄糖摄取和蛋白聚糖合成。
Matrix Biol. 2015 Sep;47:66-84. doi: 10.1016/j.matbio.2015.03.008. Epub 2015 Mar 31.
4
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.ADAMTS5 基因敲除并不消除软骨聚集素酶活性，但可阻断关节纤维化并促进软骨聚集素在小鼠骨关节炎模型中的沉积。
J Orthop Res. 2011 Apr;29(4):516-22. doi: 10.1002/jor.21215. Epub 2010 Oct 26.
5
ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy.ADAMTS5 对于机械刺激诱导的小鼠腱病愈合是必需的。
J Orthop Res. 2013 Oct;31(10):1540-8. doi: 10.1002/jor.22398. Epub 2013 Jun 10.
6
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.解整合素样金属蛋白酶与血小板反应素-1 重复域 15 的生物合成与表达：一种新型的蛋白聚糖酶切割 versican。
J Biol Chem. 2013 Dec 27;288(52):37267-76. doi: 10.1074/jbc.M112.418624. Epub 2013 Nov 12.
7
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.含血小板反应蛋白基序的解聚素样金属蛋白酶可产生调节指间蹼退化的活性多功能蛋白聚糖片段。
Dev Cell. 2009 Nov;17(5):687-98. doi: 10.1016/j.devcel.2009.09.008.
8
Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5.由于 ADAMTS5 的敲除，聚集蛋白聚糖的积累对鼠肌腱功能有不良影响。
J Orthop Res. 2012 Apr;30(4):620-6. doi: 10.1002/jor.21558. Epub 2011 Sep 16.
9
Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines.Adamts5（聚集蛋白聚糖酶-2）在鼠的肌肉骨骼系统中广泛表达，并可被炎性细胞因子在膝关节外植体的特定区域诱导。
J Orthop Res. 2012 Feb;30(2):226-33. doi: 10.1002/jor.21508. Epub 2011 Jul 28.
10
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.ADAMTS5是小鼠软骨在体内和体外的主要聚集蛋白聚糖酶。
Nature. 2005 Mar 31;434(7033):648-52. doi: 10.1038/nature03417.

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The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency.ADAMTS5 缺乏会破坏髁突对增加负荷的适应性反应。
Connect Tissue Res. 2023 Jan;64(1):93-104. doi: 10.1080/03008207.2022.2102491. Epub 2022 Aug 1.
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ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.ADAMTS-5在主动脉夹层患者的主动脉和血浆中减少，并减轻血管紧张素II诱导的平滑肌细胞凋亡。
Front Cardiovasc Med. 2020 Aug 14;7:136. doi: 10.3389/fcvm.2020.00136. eCollection 2020.
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Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction.细胞外基质组成与重塑：关于继发腭形成、唇腭裂及腭重建的当前观点
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ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer.ADAMTS5 通过抑制人胃癌中的迁移、侵袭和血管生成发挥肿瘤抑制作用。
Gastric Cancer. 2019 Mar;22(2):287-301. doi: 10.1007/s10120-018-0866-2. Epub 2018 Aug 13.
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The Zonal Architecture of the Mandibular Condyle Requires ADAMTS5.下颌骨髁突的分区结构需要 ADAMTS5。
J Dent Res. 2018 Nov;97(12):1383-1390. doi: 10.1177/0022034518777751. Epub 2018 Jun 7.
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Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.ADAMTS5的表观遗传沉默与结直肠癌患者侵袭性增加及预后不良相关。
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