丝氨酸蛋白酶抑制剂-酶受体 低密度脂蛋白受体相关蛋白1
Serpin-Enzyme Receptors LDL Receptor-Related Protein 1.
作者信息
Strickland Dudley K, Muratoglu Selen Catania, Antalis Toni M
机构信息
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.
出版信息
Methods Enzymol. 2011;499:17-31. doi: 10.1016/B978-0-12-386471-0.00002-X.
Abstract
Early studies suggested the existence of an hepatic receptor that is involved in the clearance of serpin:enzyme complexes. Subsequent work has identified this receptor as the LDL receptor-related protein 1 (LRP1). LRP1 is a multifunctional receptor that serves to transport numerous molecules into the cell via endocytosis and also serves as a signaling receptor. LRP1 plays diverse roles in biology, including roles in lipoprotein metabolism, regulation of protease activity, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses. Deletion of the Lrp1 gene leads to lethality in mice, revealing a critical, but as of yet undefined, role in development. Its identification as a receptor for serpin:enzyme complexes confirms a major role for LRP1 in regulating protease activity.
摘要
早期研究表明存在一种参与丝氨酸蛋白酶抑制剂
酶复合物清除的肝脏受体。随后的研究工作已将该受体鉴定为低密度脂蛋白受体相关蛋白1（LRP1）。LRP1是一种多功能受体，它通过内吞作用将众多分子转运到细胞内，并且还作为信号受体。LRP1在生物学中发挥着多种作用，包括在脂蛋白代谢、蛋白酶活性调节、溶酶体酶激活以及细菌毒素和病毒的细胞进入等方面的作用。Lrp1基因的缺失会导致小鼠死亡，这揭示了其在发育过程中的关键但尚未明确的作用。它作为丝氨酸蛋白酶抑制剂：酶复合物的受体的鉴定证实了LRP1在调节蛋白酶活性方面的主要作用。
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