University of Edinburgh, Edinburgh, UK.
Clin Oncol (R Coll Radiol). 2011 Aug;23(6):387-92. doi: 10.1016/j.clon.2011.03.003. Epub 2011 Jun 16.
Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies, such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP is a different entity to inflammatory or neuropathic pain and needs to be considered as such. This overview examines the mechanisms of CIBP; the imbalance of bone turnover, peripheral and central nervous involvement and key neurochemical mediators. The current understanding of the underlying pathophysiology of CIBP is discussed.
癌症相关性骨痛（CIBP）较为常见，且治疗具有挑战性。阿片类药物、放疗和双膦酸盐等常用疗法往往仅部分有效。CIBP 有别于炎性或神经性疼痛，需要将其视为一种独特的疾病。本文综述了 CIBP 的发病机制，包括骨转换失衡、外周和中枢神经系统受累以及关键神经化学介质。本文还探讨了目前对 CIBP 潜在病理生理学的认识。
