Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.
J Neurol Sci. 2011 Sep 15;308(1-2):88-93. doi: 10.1016/j.jns.2011.05.047. Epub 2011 Jun 17.
Major vault protein (MVP) is a vesicular drug transporter and may participate in multidrug resistance (MDR). The aim of this study was to determine the expression and cellular localization of MVP in refractory frontal lobe epilepsy (FLE). We detected MVP expression in tissue samples from the refractory frontal cortex of 30 patients who had been surgically treated for refractory epilepsy. We compared these tissues with twelve histologically normal frontal lobe samples from controls. In the control group, the expression of MVP was faint in the cortex. The expression of MVP protein increased dramatically in the refractory epilepsy group; MVP immunoreactivity (IR) was observed in the cytoplasm of neurons. Thus, MVP protein was increased in the frontal cortex of patients with refractory epilepsy. Further research is necessary to determine whether or not MVP plays a role in the mechanisms underlying drug resistance in refractory FLE.
主要穹窿蛋白 (MVP) 是一种囊泡药物转运体，可能参与多药耐药 (MDR)。本研究旨在确定 MVP 在难治性额颞叶癫痫 (FLE) 中的表达和细胞定位。我们检测了 30 例接受手术治疗难治性癫痫的患者难治性额皮质组织样本中的 MVP 表达。我们将这些组织与对照组的 12 个组织学正常的额叶样本进行了比较。在对照组中，MVP 在皮质中的表达较弱。在难治性癫痫组中，MVP 蛋白的表达显著增加；MVP 免疫反应性 (IR) 观察到在神经元的细胞质中。因此，难治性癫痫患者的额皮质中 MVP 蛋白增加。需要进一步研究以确定 MVP 是否在难治性 FLE 耐药机制中起作用。
