Souza Marques University, Rio de Janeiro, Brazil.
Am J Obstet Gynecol. 2011 Aug;205(2):115.e1-5. doi: 10.1016/j.ajog.2011.03.011. Epub 2011 Mar 16.
The objective of the study was to evaluate the risk of anal squamous intraepithelial lesions (ASILs) in immunocompetent women with genital squamous intraepithelial lesions (GSILs).
This was a cross-sectional study that included 260 immunocompetent women divided into 2 study groups: 1 group included 184 women diagnosed with GSIL by genital colposcopy and biopsy, and the other included 76 controls. All subjects were submitted to anoscopy followed by a biopsy if pertinent.
Of 184 GSIL women, 32 (17.4%) had ASIL (P<.001). The risk of ASIL was 13.1 times greater for GSIL women when there were 3 or 4 genital sites involved. All cases of high-grade ASIL were found in women with cervical GSILs. Among risk factors, anal intercourse without a condom demonstrated an important association with ASIL (prevalence ratio adjusted for age=2.6).
There seems to be a strong association between ASIL and multicentric GSIL. Another factor related to ASIL was the practice of unprotected anal intercourse.
本研究旨在评估免疫功能正常的女性生殖器鳞状上皮内病变（GSIL）患者发生肛门鳞状上皮内病变（ASIL）的风险。
这是一项横断面研究，纳入了 260 名免疫功能正常的女性，分为两组：一组 184 名女性经生殖器阴道镜和活检诊断为 GSIL，另一组 76 名为对照组。所有受试者均接受肛门镜检查，如果有必要则进行活检。
在 184 名 GSIL 女性中，有 32 名（17.4%）患有 ASIL（P<.001）。当涉及 3 或 4 个生殖器部位时，GSIL 女性发生 ASIL 的风险增加 13.1 倍。所有高级别 ASIL 病例均发生在宫颈 GSIL 女性中。在危险因素中，无保护的肛门性交与 ASIL 有重要关联（调整年龄后的患病率比=2.6）。
ASIL 与多中心 GSIL 之间似乎存在密切关联。与 ASIL 相关的另一个因素是无保护的肛门性交。
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