DeFord J A, Babbs C F, Patel U H, Fearnot N E, Marchosky J A, Moran C J
Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, IN 47907.
Int J Hyperthermia. 1990 Jul-Aug;6(4):755-69. doi: 10.3109/02656739009140823.
Accurate knowledge of tissue temperature is necessary for effective delivery of clinical hyperthermia in the treatment of malignant tumours. This report compares computer-predicted versus measured intratumoral temperatures in 11 human subjects with intracranial tumours, treated with a conceptually simple 'conductive' interstitial hyperthermia system. Interstitial hyperthermia was achieved by the use of parallel arrays of implanted, electrically heated catheters. The tissue was warmed by thermal conduction and blood convection. Simulation of intratumoral temperatures was achieved by solving a modified bioheat transfer equation on a digital computer using a finite difference method. Comparison of intratumoral temperatures from simulations and measured values differed by about +/- 0.75 degrees C. Further analysis of computed temperature distributions between catheters revealed a rapidly computable relationship between the local minimum tumour temperature and nearby catheter power and temperature that accounts for effects of varying blood flow. These findings suggest that 'on-line' prediction and control of local minimum tumour temperatures are feasible with the conductive interstitial technique.
准确了解组织温度对于在恶性肿瘤治疗中有效实施临床热疗至关重要。本报告比较了11例颅内肿瘤患者在接受概念上简单的“传导性”组织间热疗系统治疗时，计算机预测的肿瘤内温度与实测温度。组织间热疗通过使用植入的电加热导管平行阵列来实现。组织通过热传导和血液对流升温。通过在数字计算机上使用有限差分法求解修正的生物热传递方程来模拟肿瘤内温度。模拟温度与实测温度的比较相差约±0.75℃。对导管间计算出的温度分布的进一步分析揭示了局部最低肿瘤温度与附近导管功率和温度之间的快速可计算关系，该关系考虑了血流变化的影响。这些发现表明，采用传导性组织间技术对局部最低肿瘤温度进行“在线”预测和控制是可行的。
