Institute of Chemical and Engineering Sciences, Organic Chemistry, 11 Biopolis Way, Helios, Singapore 138667, Singapore.
Curr Opin Chem Biol. 2011 Aug;15(4):516-22. doi: 10.1016/j.cbpa.2011.05.022. Epub 2011 Jun 22.
There is a paucity of chemical matter suitably poised for effective drug development. Improving the quality and efficiency of research early on in the drug discovery process has been a long standing objective for the drug industry and improvements to the accessibility and quality of compound screening decks might have a significant and positive impact. In the absence of specific molecular information that can be modeled and used predicatively we are far from identifying which small molecules are most relevant to emerging biological targets such as protein-protein interactions. Natural products have been historically successful as an entry point for drug discovery and recently screening libraries are being synthesized to emulate natural product like features.
可供有效药物开发的化学物质非常有限。提高药物发现过程早期研究的质量和效率一直是制药行业的长期目标，提高化合物筛选库的可及性和质量可能会产生重大而积极的影响。在缺乏可建模和预测使用的特定分子信息的情况下，我们远未确定哪些小分子与新兴的生物靶点（如蛋白质-蛋白质相互作用）最相关。天然产物在药物发现方面一直具有成功的历史，最近正在合成筛选库以模拟天然产物的特征。
