Béchade Dominique
Institut Bergonié, groupe digestif, 229, cours de l’Argonne, 33076 Bordeaux Cedex, France.
Bull Cancer. 2011 Jul;98(7):827-36. doi: 10.1684/bdc.2011.1396.
Screening high-risk individuals with imaging tests, such as endoscopic ultrasound and computed tomography, can lead to the detection and treatment of predominantly asymptomatic premalignant lesions. These pancreatic lesions consist of resectable, mostly branch-type non-invasive intraductal papillary mucinous neoplasms. Endoscopic ultrasound features of chronic pancreatitis are highly prevalent in high-risk individuals and these directly correlate with multifocal lobulocentric parenchymal atrophy due to pancreatic intraepithelial neoplasia. Long-term, multi-prospective studies are needed to determine if screening for early pancreatic adenocarcinoma and timely intervention will result in decreased pancreatic cancer incidence and mortality in high-risk individuals.
使用内镜超声和计算机断层扫描等影像学检查对高危个体进行筛查，可检测并治疗主要为无症状的癌前病变。这些胰腺病变包括可切除的、大多为分支型的非侵袭性导管内乳头状黏液性肿瘤。慢性胰腺炎的内镜超声特征在高危个体中非常普遍，并且这些特征与胰腺上皮内瘤变导致的多灶性小叶中心性实质萎缩直接相关。需要进行长期的多前瞻性研究，以确定早期胰腺癌筛查和及时干预是否会降低高危个体的胰腺癌发病率和死亡率。
