Meeker R B, Michels K M, Hayward J N
Department of Neurology and Neurobiology Curriculum, University of North Carolina, Chapel Hill 27599.
Neurosci Lett. 1990 Jul 3;114(2):225-30. doi: 10.1016/0304-3940(90)90076-l.
Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskolin elicited a 3-fold greater increase in cyclic AMP in the neural lobe than in the supraoptic nucleus and enhanced the sensitivity of the tissues to both vasopressin and oxytocin. The ability of both vasopressin and oxytocin to modulate local cyclic AMP metabolism suggests the possibility of internal feedback within the hypothalamo-neurohypophysial system.
在体外向下丘脑 - 神经垂体外植体中添加血管加压素可增加环磷酸腺苷（cAMP）的积累，而外源性催产素则降低cAMP水平。在垂体神经叶中观察到相反的反应模式，血管加压素降低而催产素增加cAMP积累。福斯高林在神经叶中引起的cAMP增加幅度比视上核大3倍，并增强了组织对血管加压素和催产素的敏感性。血管加压素和催产素调节局部cAMP代谢的能力表明下丘脑 - 神经垂体系统内存在内反馈的可能性。
