van de Ven Annick A J M, Douma Jan Willem, Rademaker Carin, van Loon Anton M, Wensing Annemarie M J, Boelens Jaap-Jan, Sanders Elisabeth A M, van Montfrans Joris M
Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, the Netherlands.
Antivir Ther. 2011;16(4):611-4. doi: 10.3851/IMP1792.
A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immunocompromised host.
一名14岁的普通可变免疫缺陷患者出现了严重的蛋白丢失性肠病。诊断为1型人细小核糖核酸病毒和诺如病毒的慢性肠道感染。旨在根除病毒并提供支持性护理的治疗策略无效。抗小核糖核酸病毒药物普来可那立对病毒复制没有任何作用。免疫抑制治疗后症状有所改善，提示免疫功能低下宿主中存在感染相关的免疫失调。
