Naruka K, Bhartiya H C
Department of Zoology, University of Rajasthan, Jaipur, India.
Strahlenther Onkol. 1990 Aug;166(8):542-4.
S-2 (3-aminopropylamino) ethyl phosphorothioic acid (WR-2721) has been investigated for its ability to protect pronormoblasts and normoblasts against radiation damage. Male Swiss albino mice were exposed to three different doses (2.5, 5 and 10 Gy) of gamma radiation from a 60Co source with or without the drug (at a dose of 300 mg/kg body weight). They were sacrificed at various intervals from twelve hours to 28 days and bone marrow films were prepared for counting. The results indicated that pronormoblasts and normoblasts decreased after all the three exposures both in control and experimental groups, but in the drug treated groups, counts were always higher than their respective controls and recovery was also faster. It is, therefore, concluded that WR-2721 shows an appreciable protective potential against radiation induced changes.
S-2（3-氨丙基氨基）乙基硫代磷酸（WR-2721）已被研究其保护早幼红细胞和幼红细胞免受辐射损伤的能力。雄性瑞士白化小鼠接受来自60Co源的三种不同剂量（2.5、5和10 Gy）的γ辐射，有或没有药物（剂量为300 mg/kg体重）。在12小时至28天的不同时间间隔处死它们，并制备骨髓涂片进行计数。结果表明，对照组和实验组在所有三种照射后早幼红细胞和幼红细胞均减少，但在药物治疗组中，细胞计数始终高于各自的对照组，且恢复也更快。因此，得出结论，WR-2721对辐射诱导的变化显示出明显的保护潜力。
