Thomas B, Devi P U
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Strahlenther Onkol. 1987 Dec;163(12):807-10.
The radioprotective action of thiol compounds 2-mercaptopropionylglycine (MPG) and S-2(aminopropylamino) ethyl phosphorothioic acid (WR-2721) was evaluated either alone or in combination on the bone marrow chromosomes of Swiss albino mice after 4.5 Gy of 60Co radiation. Single drug administration of WR-2721 at 300 mg/kg body weight resulted in a 50% reduction in the yield of aberrant cells at 24 hours post irradiation, while the other single drug doses were less effective. The combination of the two drugs increased the effect in the sense that 150 mg/kg WR-2721 with 20 mg/kg MPG gave equal protection as 300 mg/kg WR-2721 given alone. Moreover, on day 14, when WR-2721 produced an increase in the precent aberrant cells the above combination brought down the value to normal. It appears that MPG neutralizes to some extent the toxic effect of WR-2721, without impairing the protective efficiency.
在给予瑞士白化小鼠4.5 Gy的60Co辐射后，评估了硫醇化合物2-巯基丙酰甘氨酸（MPG）和S-2（氨丙基氨基）乙基硫代磷酸（WR-2721）单独或联合使用对其骨髓染色体的辐射防护作用。以300 mg/kg体重单次给药WR-2721，在照射后24小时可使异常细胞产量降低50%，而其他单次给药剂量的效果较差。两种药物联合使用增强了效果，即150 mg/kg WR-2721与20 mg/kg MPG联合使用所提供的保护与单独给予300 mg/kg WR-2721相同。此外，在第14天，当WR-2721使异常细胞百分比增加时，上述联合用药可使其值降至正常。似乎MPG在一定程度上中和了WR-2721的毒性作用，而不损害其保护效率。
