Stolkarts I Z, Sekach S F
Zh Vopr Neirokhir Im N N Burdenko. 1990 May-Jun(3):24-7.
The article deals with the analysis of changes in cerebrospinal fluid pressure (CSFP), mean arterial pressure (MAP), brain perfusion pressure (BPR), and central venous pressure (CVP) during general anesthesia in 172 patients with tumorous, tumor-like, and vascular diseases of the brain. CSFP increased sharply during preanesthesia, in administration of inhalation anesthetics, and under the effect of inadequate anesthesia during trephination of the skull. The rise in CSFP in preanesthesia can be reduced by a combination of barbiturates with neuroleptanalgesics the administration of which is continued for up to 2-3 minutes of artificial lung ventilation through a mask. To correct the rise in CSFP during the use of 70% N2O, the authors recommend preliminary 5-10-minute anesthesia with a N2O + O2 (50:50) mixture and administration of sodium thiopental (2-3 mg/kg) or seduxen (0.2-0.3 mg/kg) in the first minutes of the postintubation period.
本文分析了172例患有脑部肿瘤、类肿瘤及血管疾病患者在全身麻醉期间脑脊液压力（CSFP）、平均动脉压（MAP）、脑灌注压（BPR）和中心静脉压（CVP）的变化。在麻醉前、吸入麻醉药给药期间以及颅骨钻孔时麻醉不足的情况下，CSFP会急剧升高。麻醉前CSFP的升高可通过巴比妥类药物与神经安定镇痛剂联合使用来降低，其给药持续至通过面罩进行人工肺通气2 - 3分钟。为纠正使用70% N2O期间CSFP的升高，作者建议在插管后最初几分钟用N2O + O2（50:50）混合气体进行5 - 10分钟的预麻醉，并给予硫喷妥钠（2 - 3 mg/kg）或速眠新（0.2 - 0.3 mg/kg）。
