维生素B12缺乏症中的神经退行性变。
Neuro-regression in vitamin B12 deficiency.
作者信息
Agrawal Sanwar, Nathani Shweta
机构信息
Ekta Institute of Child Health, Pediatrics, Near Ram Mandir, Shantinagar, Raipur 492001, India.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2008.0235. Epub 2009 Mar 17.
Abstract
Neuroregression in infants has varied aetiology and vitamin B12 deficiency is one of the uncommon causes. Infantile vitamin B12 deficiency is encountered in malnourished infants or in offspring of strict vegan mothers. We present two cases, both infants of 10 and 8 months of age, whose mothers had vitamin B12 deficiency. On admission, the patients were apathic, hypotonic and lethargic. Serum vitamin B12 levels were below normal limits. On cranial MRI, T2-weighted images revealed frontoparietal cortical atrophy. Both the infants responded to vitamin B12 treatment.
摘要
婴儿神经退行性变病因多样，维生素B12缺乏是其中不常见的病因之一。婴儿维生素B12缺乏见于营养不良的婴儿或严格素食母亲的后代。我们报告两例病例，均为10个月和8个月大的婴儿，其母亲有维生素B12缺乏。入院时，患儿表现为冷漠、肌张力低下和嗜睡。血清维生素B12水平低于正常范围。头颅MRI的T2加权像显示额顶叶皮质萎缩。两名婴儿对维生素B12治疗均有反应。
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