Purdy Georgiana E
Department of Molecular Microbiology and Immunology, Oregon Health Sciences University Portland, OR, USA.
Front Microbiol. 2011 Jan 31;2:7. doi: 10.3389/fmicb.2011.00007. eCollection 2011.
Tuberculosis remains a significant global health concern. The hallmark of Mycobacterium tuberculosis pathogenicity is its ability to infect resting macrophages and establish an intracellular niche. Activated and autophagic macrophages control mycobacterial infections through bactericidal mechanisms ranging from reactive oxygen and nitrogen intermediates to the delivery of the bacterium to the acidified, hydrolytically active lysosome. The mycobactericidal activity of the lysosome is due in part to the action of ubiquitin-derived peptides (Ub-peptides). In this review we discuss the trafficking events that result in delivery M. tuberculosis to the lysosome, the source and lysosomal generation of Ub-peptides and their role in macrophage control of M. tuberculosis infection.
结核病仍然是一个重大的全球健康问题。结核分枝杆菌致病性的标志是其感染静息巨噬细胞并在细胞内建立生态位的能力。活化的自噬巨噬细胞通过从活性氧和氮中间体到将细菌递送至酸化的、具有水解活性的溶酶体等杀菌机制来控制分枝杆菌感染。溶酶体的杀分枝杆菌活性部分归因于泛素衍生肽（Ub肽）的作用。在本综述中，我们讨论了导致结核分枝杆菌被递送至溶酶体的运输事件、Ub肽的来源和溶酶体生成及其在巨噬细胞控制结核分枝杆菌感染中的作用。
