Schuelein Ralf, Ang Desmond K Y, van Driel Ian R, Hartland Elizabeth L
Department of Microbiology and Immunology, University of Melbourne Parkville, Victoria, Australia.
Front Microbiol. 2011 Jun 3;2:126. doi: 10.3389/fmicb.2011.00126. eCollection 2011.
Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of L. pneumophila infection in the lung requires multiple cell types and abundant cross talk between immune cells. Few studies have examined the coordination of events that lead to effective immune control of the pathogen. Here we discuss L. pneumophila interactions with macrophages and dendritic cell subsets and highlight the paucity of knowledge around how these interactions recruit and activate other immune effector cells in the lung.
嗜肺军团菌是一种在肺泡巨噬细胞内复制的细胞内病原体。通过激活多种宿主固有免疫成分的能力，嗜肺军团菌已成为剖析巨噬细胞炎症信号通路的有用工具。然而，肺部嗜肺军团菌感染的消退需要多种细胞类型以及免疫细胞之间大量的相互作用。很少有研究探讨导致对该病原体进行有效免疫控制的事件的协调情况。在这里，我们讨论嗜肺军团菌与巨噬细胞和树突状细胞亚群的相互作用，并强调围绕这些相互作用如何招募和激活肺部其他免疫效应细胞的知识匮乏。
