Dunphy Sinéad, Gardiner Clair M
NK Cell Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.
J Biomed Biotechnol. 2011;2011:248317. doi: 10.1155/2011/248317. Epub 2011 May 26.
Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines influencing keratinocyte function. Keratinocytes in turn, can activate and recruit immune cells leading to a positive feedback loop in disease. Natural Killer (NK) cells are lymphocytes that are best known for killing virally infected and cancer cells. However, evidence is emerging to support a role for NK cells in psoriasis. NK cells are found in the inflammatory infiltrate in psoriatic skin lesions. They can produce a range of inflammatory cytokines, many of which are important in the pathogenesis of psoriasis. Recent genetic studies have identified a range of potential molecules relating to NK cell biology that are known to be important in psoriasis. This paper will discuss the evidence, both cellular and genetic, for NK cell involvement in psoriasis.
银屑病是一种慢性皮肤病，其特征为独特的鳞屑斑块。目前认为免疫系统在银屑病的发生和发病机制中起主要作用，免疫细胞和细胞因子会影响角质形成细胞的功能。反过来，角质形成细胞可以激活并募集免疫细胞，从而导致疾病中的正反馈循环。自然杀伤（NK）细胞是淋巴细胞，因其能够杀伤病毒感染细胞和癌细胞而最为人所知。然而，越来越多的证据支持NK细胞在银屑病中发挥作用。在银屑病皮肤病变的炎性浸润中可发现NK细胞。它们可以产生一系列炎性细胞因子，其中许多在银屑病的发病机制中很重要。最近的遗传学研究已经确定了一系列与NK细胞生物学相关的潜在分子，这些分子在银屑病中很重要。本文将讨论NK细胞参与银屑病的细胞和遗传学证据。
