雌激素在甲状腺功能及生长调节中的作用。
Role of estrogen in thyroid function and growth regulation.
作者信息
Santin Ana Paula, Furlanetto Tania Weber
机构信息
Postgraduation Program in Medicine and Medical Sciences, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.
出版信息
J Thyroid Res. 2011;2011:875125. doi: 10.4061/2011/875125. Epub 2011 May 4.
Abstract
Thyroid diseases are more prevalent in women, particularly between puberty and menopause. It is wellknown that estrogen (E) has indirect effects on the thyroid economy. Direct effects of this steroid hormone on thyroid cells have been described more recently; so, the aim of the present paper was to review the evidences of these effects on thyroid function and growth regulation, and its mechanisms. The expression and ratios of the two E receptors, α and β, that mediate the genomic effects of E on normal and abnormal thyroid tissue were also reviewed, as well as nongenomic, distinct molecular pathways. Several evidences support the hypothesis that E has a direct role in thyroid follicular cells; understanding its influence on the growth and function of the thyroid in normal and abnormal conditions can potentially provide new targets for the treatment of thyroid diseases.
摘要
甲状腺疾病在女性中更为常见，尤其是在青春期和更年期之间。众所周知，雌激素（E）对甲状腺功能有间接影响。最近已经描述了这种类固醇激素对甲状腺细胞的直接作用；因此，本文的目的是综述这些作用对甲状腺功能和生长调节及其机制的证据。还综述了介导E对正常和异常甲状腺组织基因组效应的两种E受体α和β的表达及比例，以及非基因组的、独特的分子途径。有若干证据支持E在甲状腺滤泡细胞中具有直接作用这一假说；了解其在正常和异常情况下对甲状腺生长和功能的影响可能为甲状腺疾病的治疗提供新的靶点。
相似文献
1
Role of estrogen in thyroid function and growth regulation.
J Thyroid Res. 2011;2011:875125. doi: 10.4061/2011/875125. Epub 2011 May 4.
2
Overlapping nongenomic and genomic actions of thyroid hormone and steroids.
Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):581-93. doi: 10.1016/j.beem.2015.04.001. Epub 2015 Apr 22.
3
Comparison of the mechanisms of nongenomic actions of thyroid hormone and steroid hormones.
J Endocrinol Invest. 2002 Apr;25(4):377-88. doi: 10.1007/BF03344022.
4
Quantitative analysis of estrogen receptor-alpha and -beta messenger RNA expression in normal and malignant thyroid tissues by real-time polymerase chain reaction.
Oncology. 2001;61(4):293-8. doi: 10.1159/000055336.
5
Estrogen and its role in thyroid cancer.
Endocr Relat Cancer. 2014 Oct;21(5):T273-83. doi: 10.1530/ERC-14-0053. Epub 2014 Jul 22.
6
Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer.
Curr Cancer Drug Targets. 2008 Aug;8(5):367-77. doi: 10.2174/156800908785133150.
7
Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor alpha- and beta-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells.
Bone. 1999 May;24(5):465-73. doi: 10.1016/s8756-3282(99)00017-4.
8
Molecular Basis of Nongenomic Actions of Thyroid Hormone.
Vitam Horm. 2018;106:67-96. doi: 10.1016/bs.vh.2017.06.001. Epub 2017 Jul 8.
9
Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions.
Mod Pathol. 2003 May;16(5):437-44. doi: 10.1097/01.MP.0000066800.44492.1B.
10
Nongenomic actions of thyroid hormone.
Nat Rev Endocrinol. 2016 Feb;12(2):111-21. doi: 10.1038/nrendo.2015.205. Epub 2015 Dec 15.
引用本文的文献
1
GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential.
J Transl Med. 2025 Aug 26;23(1):960. doi: 10.1186/s12967-025-07005-0.
2
Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial).
Sci Rep. 2025 Jul 1;15(1):21059. doi: 10.1038/s41598-025-05396-0.
3
Associations between age at natural menopause and risk of hypothyroidism among postmenopausal women from the Canadian Longitudinal Study on Aging (CLSA).
PLoS One. 2025 May 28;20(5):e0324635. doi: 10.1371/journal.pone.0324635. eCollection 2025.
4
Mental Health Status of Patients with Thyroid Nodules: A Cross-Sectional Study.
J Multidiscip Healthc. 2025 May 9;18:2641-2650. doi: 10.2147/JMDH.S513795. eCollection 2025.
5
Association Between Indices of Thyroid Hormone Resistance and Constipation Prevalence in the US Population: NHANES 2007-2010.
J Clin Gastroenterol. 2024 Nov 14;59(9):889-900. doi: 10.1097/MCG.0000000000002107.
6
Evaluation of the Dysregulation of Cholesterol and Glucose Levels in Graves' Disease Using Clinical Data Analysis.
Rep Biochem Mol Biol. 2024 Jul;13(2):159-166. doi: 10.61186/rbmb.13.2.159.
7
Elevated Risk of Thyroid Malignancy in Biological Males Taking Estrogen Hormone Therapy.
Otolaryngol Head Neck Surg. 2025 Apr;172(4):1192-1198. doi: 10.1002/ohn.1128. Epub 2025 Jan 10.
8
17β-Estradiol Stimulates Oxidative Stress Components and Thyroid Specific Genes in Porcine Thyroid Follicular Cells: Potential Differences Between Sexes.
Cells. 2024 Oct 25;13(21):1769. doi: 10.3390/cells13211769.
9
Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study.
Front Oncol. 2024 Oct 14;14:1422009. doi: 10.3389/fonc.2024.1422009. eCollection 2024.
10
Correlation between estradiol-to-testosterone ratio and thyroid peroxidase antibody positivity in men with treatment-naïve primary hypothyroidism or euthyroidism.
Arch Endocrinol Metab. 2024 Jul 1;68:e230256. doi: 10.20945/2359-4292-2023-0256. eCollection 2024.
本文引用的文献
1
A postmenopausal woman with gross cystic disease fluid protein-15 and estrogen receptor-positive recurrence of papillary thyroid cancer.
Thyroid. 2010 Dec;20(12):1413-7. doi: 10.1089/thy.2010.0093. Epub 2010 Nov 7.
2
Diagnostic value of estrogen receptors in thyroid lesions.
Med Sci Monit. 2010 Jul;16(7):BR203-7.
3
Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta.
Int J Oncol. 2010 May;36(5):1067-80. doi: 10.3892/ijo_00000588.
4
Metastatic phenotype is regulated by estrogen in thyroid cells.
Thyroid. 2010 Jan;20(1):33-41. doi: 10.1089/thy.2009.0296.
5
The role of oestrogen receptor {alpha} in human thyroid cancer: contributions from coregulatory proteins and the tyrosine kinase receptor HER2.
Endocr Relat Cancer. 2010 Feb 18;17(1):255-64. doi: 10.1677/ERC-09-0216. Print 2010 Mar.
6
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.
Mol Cell Endocrinol. 2010 May 28;321(1):20-8. doi: 10.1016/j.mce.2009.10.016. Epub 2009 Nov 6.
7
Clinical and molecular features of differentiated thyroid cancer diagnosed during pregnancy.
Eur J Endocrinol. 2010 Jan;162(1):145-51. doi: 10.1530/EJE-09-0761. Epub 2009 Oct 14.
8
Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005.
Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):784-91. doi: 10.1158/1055-9965.EPI-08-0960. Epub 2009 Feb 24.
9
Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer.
Curr Cancer Drug Targets. 2008 Aug;8(5):367-77. doi: 10.2174/156800908785133150.
10
Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells.
Toxicol Sci. 2008 Oct;105(2):303-11. doi: 10.1093/toxsci/kfn141. Epub 2008 Jul 21.
Zotero 插件