Kareem Zainab Razaq, Al-Kazazz Fatin Fadhel, Rheima Ahmed Mahdi, Sultan Ameer Radhi
Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.
Department of Chemistry, Al-lmamin Al-Kadhumain Medical City Hospital, Baghdad, Iraq.
Rep Biochem Mol Biol. 2024 Jul;13(2):159-166. doi: 10.61186/rbmb.13.2.159.
Graves' disease (GD) is the most frequent reason for hyperthyroidism, which is brought on by an excess of thyroid hormone and a form of autoimmune thyroid disease (AITD). Patients with GD have higher levels of thyroid receptor antibody (TRAb). The current study, investigates the impact of excessive thyroid hormone production on glucose and cholesterol metabolism in thyroid disorders, particularly focusing on GD.
This study included 96 subjects (32 GD patients, 32 from non-autoimmune hyperthyroidism and 32 from healthy controls). All samples were obtained from Al-Kadhimiya Teaching Hospital (Baghdad) for the period between September 2023 and January 2024.
The results revealed that mean± SD values of FT3 and FT4 for GD patients were significantly higher (P<0.001) accompanied by a significant decrease in mean±SD values of TSH (P<0.001) when compared to non-autoimmune hyperthyroidism and control groups. Conversely, TC and glucose levels did not show significant variations among GD patients, the non-immune hyperthyroidism and control groups (P > 0.05).
Our findings indicated thyroid function analysis is crucial for the diagnosis and differentiation of GD, TC and glucose levels do not contribute additional discriminatory power.
格雷夫斯病（GD）是甲状腺功能亢进最常见的原因，由甲状腺激素过多引起，是一种自身免疫性甲状腺疾病（AITD）。GD患者的甲状腺受体抗体（TRAb）水平较高。本研究调查甲状腺激素过度产生对甲状腺疾病中葡萄糖和胆固醇代谢的影响，尤其关注GD。
本研究纳入96名受试者（32名GD患者、32名非自身免疫性甲状腺功能亢进患者和32名健康对照）。所有样本均于2023年9月至2024年1月期间从卡迪米亚教学医院（巴格达）采集。
结果显示，与非自身免疫性甲状腺功能亢进组和对照组相比，GD患者的FT3和FT4的平均值±标准差显著更高（P<0.001），同时TSH的平均值±标准差显著降低（P<0.001）。相反，GD患者、非免疫性甲状腺功能亢进组和对照组之间的总胆固醇（TC）和血糖水平没有显著差异（P>0.05）。
我们的研究结果表明，甲状腺功能分析对GD的诊断和鉴别至关重要，TC和血糖水平不具有额外的鉴别能力。
